Short-Term Physical Inactivity Induces Endothelial Dysfunction
نویسندگان
چکیده
منابع مشابه
Physical inactivity increases oxidative stress, endothelial dysfunction, and atherosclerosis.
OBJECTIVE Sedentary lifestyle is associated with increased cardiovascular events. The underlying molecular mechanisms are incompletely understood. Reactive oxygen species (ROS) contribute to endothelial dysfunction and atherosclerosis. An important source of vascular ROS is the NADPH oxidase. METHODS AND RESULTS C57BL6 mice were subjected to regular housing (physical inactivity) or voluntary ...
متن کاملPhysical inactivity causes endothelial dysfunction in healthy young mice.
OBJECTIVES We sought to determine if physical inactivity affects endothelial function in young healthy individuals. BACKGROUND Recent studies have linked exercise training to increased bioavailability of vascular nitric oxide (NO) and to improved endothelial function in patients with cardiovascular disorders. The effects of physical inactivity on normal vascular endothelial function are not k...
متن کاملPhysical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers.
OBJECTIVE Sedentary lifestyle increases the risk of cardiovascular disease and diabetes. Vascular dysfunction contributes to atherogenesis and has been linked to insulin resistance. METHODS AND RESULTS We measured insulin sensitivity by glucose tolerance test and vascular function by ultrasound and venous occlusion plethysmography in 20 healthy subjects (14 men, 6 women) at baseline and durin...
متن کاملPhysical inactivity and short-term all-cause mortality in adults with chronic disease.
OBJECTIVE To ascertain the relationship of physical inactivity and short-term all-cause mortality in a prospective cohort of randomly selected managed care organization members aged 40 years and older who have multiple chronic diseases. METHODS Clinical databases were used to identify all health plan members aged 40 years and older with 2 or more chronic health conditions (hypertension, coron...
متن کاملPhysical exercise and endothelial dysfunction.
The role of the endothelium was considered mainly as a selective barrier for the diffusion of macromolecules from the lumen of blood vessels to the interstitial space. During the last 20 years, many other functions have been defined for the endothelium, such as the regulation of the vagal tonus, the promotion and inhibition of neovascular growth and the modulation of inflammation, of platelet a...
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ژورنال
عنوان ژورنال: Frontiers in Physiology
سال: 2021
ISSN: 1664-042X
DOI: 10.3389/fphys.2021.659834